Table 2.

Responder analysis of the effect of agalsidase alfa on kidney function in male patients with Fabry diseasea

Baseline CategorynResponder Definition (%)
IIIIII
90 to 135 ml/min per 1.73 m233768885
60 to 89 ml/min per 1.73 m236537578
30 to 59 ml/min per 1.73 m214434371
Proteinuria <300 mg/24 h31748787
Proteinuria ≥300 and <1000 mg/24 h27597474
Proteinuria ≥1000 mg/24 h22275064
  • a I, rate of loss of GFR ≤5 ml/min per 1.73 m2/yr30; II, <20% decrease in GFR from baseline25; III, no shift to more severe GFR category.