Table 1.

Baseline hemodynamic and excretory dataa

GroupMean AP (mmHg)RBF (ml min−1 g KW−1)HR (min−1)UV (μl min−1)n
Wild-type control85 ± 57.3 ± 1.2523 ± 3211 ± 26
Cx40-ko control100 ± 56.7 ± 1.3533 ± 2213 ± 36
Cx40KI45 control96 ± 69.1 ± 0.9539 ± 2718 ± 25
Wild-type L-NAME122 ± 4c4.1 ± 0.5b416 ± 4711 ± 34
Cx40-ko L-NAME123 ± 74.1 ± 1.1b415 ± 9b19 ± 14
Cx40KI45 L-NAME121 ± 8b5.8 ± 0.5b482 ± 2418 ± 24
  • a HR, heart rate; KW, kidney weight; UV, bilateral urine flow rate. Mean ± SEM.

  • b P < 0.05 and

  • c P < 0.001 versus the paired control before L-NAME inhibition in the same animal (paired t test).