Table 2.

Characteristics of RBF autoregulation in response to a step increase in renal arterial pressurea

GroupTotal Steady-State Autoregulation from Prestep to ∼100 sAutoregulatory Contributions (% of Perfect Autoregulation)n
Myogenic Response from ∼1 to ∼5 sTGF and Fourth Mechanism from ∼5 to ∼25 sThird Mechanism from ∼25 to ∼100 s
Wild-type control102 ± 1122 ± 675 ± 1027 ± 76
Cx40-ko control24 ± 17b23 ± 718 ± 8b18 ± 76
Cx40KI45 control66 ± 1729 ± 840 ± 11d18 ± 35
Wild-type L-NAME102 ± 578 ± 12c28 ± 8c16 ± 94
Cx40-ko L-NAME58 ± 665 ± 8c4 ± 615 ± 64
Cx40KI45 L-NAME74 ± 1662 ± 3c17 ± 518 ± 114
  • a Mean ± SEM.

  • b P < 0.01 versus the respective wt (ANOVA).

  • d P < 0.05 versus the respective wt.

  • c P < 0.05 versus the paired control before L-NAME in the same animal (paired t test).