Table 3.

Cardiovascular responses to bolus injections of NE and ACha

Group% Change from Baselinen
APRBFRVR
NE
Wild-type control+49 ± 3−53 ± 8+275 ± 605
Cx40-ko control+28 ± 2e−61 ± 1+255 ± 134
Cx40KI45 control+48 ± 7−46 ± 9+207 ± 494
Wild-type L-NAME+24 ± 4d−82 ± 6+6741 ± 5594f4
Cx40-ko L-NAME+29 ± 3−78 ± 2c+581 ± 61c4
Cx40KI45 L-NAME+27 ± 4−67 ± 5+328 ± 654
ACh
Wild-type control−43 ± 2+23 ± 11−25 ± 84
Cx40-ko control−37 ± 1+14 ± 4−23 ± 34
Cx40KI45 control−35 ± 5+13 ± 3−21 ± 74
Wild-type L-NAME−38 ± 2+20 ± 5−38 ± 34
Cx40-ko L-NAME−38 ± 2+28 ± 5b−36 ± 3b4
Cx40KI45 L-NAME−34 ± 8+13 ± 4−25 ± 54
  • a Mean ± SEM.

  • b P < 0.05,

  • c P < 0.01, and

  • d P < 0.001 versus the paired control before L-NAME in the same animal (paired t test).

  • e P < 0.05 versus respective wild-type.

  • f SEM is high, because in one animal RBF almost ceased in response to NE during L-NAME, resulting in a very large resistance value.