Table 3.

Associations of circulating calcitriol (1,25-dihydroxyvitamin D) concentration with prevalent and incident CAC in the MESAa

ParameterRR (95% CI)P
Prevalent CAC
    model 1b1.09 (1.02 to 1.16)0.01
    model 2c1.08 (1.01 to 1.15)0.018
    model 3d1.06 (1.00 to 1.13)0.065
    model 4e1.06 (1.00 to 1.13)0.064
Incident CAC
    model 1b1.18 (0.84 to 1.67)0.35
    model 2c1.19 (0.88 to 1.60)0.26
    model 3d1.22 (0.91 to 1.65)0.10
    model 4e1.32 (0.95 to 1.85)0.11
  • aRR is assessed per 10-pg/ml lower calcitriol concentration.

  • bAdjusted for age, gender, race/ethnicity, site, season, and measurement batch.

  • cAdditionally adjusted for physical activity, BMI, and smoking.

  • dAdditionally adjusted for diabetes, BP, CRP, total cholesterol, HDL cholesterol, and triglycerides.

  • eAdditionally adjusted for eGFR and serum phosphorous concentration.