Table 1.

Baseline characteristics of participants (N = 10,640)a

VariableValue
Age (yr; mean [SD])66 (6)
Female (n [%])4522 (43)
Duration of diabetes (yr; median [IQR])7 (3 to 11)
Kidney factors
    UACR (mg/g; median [IQR])15.0 (7.1 to 39.8)
        <30 (n [%])7377 (69)
        30 to 300 (n [%])2862 (27)
        >300 (n [%])401 (4)
    serum creatinine (μmol/L; median [IQR])84.0 (70.7 to 97.2)
    eGFR (ml/min per 1.73 m2; median [IQR])75.9 (63.6 to 89.7)
        eGFR ≥90 (n [%])2611 (25)
        eGFR 60 to 89 (n [%])5996 (56)
        eGFR <60 (n [%])2033 (19)
BP (mmHg)
    SBP (mean [SD])145 (21)
    DBP (mean [SD])81 (11)
    history of currently treated hypertension (n [%])7289 (69)
Previous vascular disease (n [%])
    history of macrovascular disease3394 (32)
        history of myocardial infarction1250 (12)
        history of stroke971 (9)
Other major risk factors
    HbA1c (%; mean [SD])7.5 (1.5)
    serum total cholesterol (mmol/L; mean [SD])5.2 (1.2)
    serum LDL cholesterol (mmol/L; mean [SD])3.1 (1)
    serum HDL cholesterol (mmol/L; mean [SD])1.3 (0.4)
    serum triglycerides (mmol/L; median [IQR])1.6 (1.2 to 2.3)
    BMI (kg/m2; mean [SD])28.3 (5.2)
    electrocardiogram abnormalities (n [%])b1863 (18)
    current smoker (n [%])1594 (15)
    current drinker (n [%])3212 (30)
Randomized treatment
    perindopril-indapamide (n [%])5313 (50)
  • aDBP, diastolic BP; IQR, interquartile range.

  • bElectrocardiogram abnormalities were defined as presence of Q waves consistent with previous myocardial infarction, left ventricular hypertrophy and artrial fibrillation.