Table 3.

Light microscopic findingsa

Pathologic FindingsValue
No. of glomeruli (mean)17.7
% of globally sclerotic glomeruli (mean)17.5
Predominant histologic pattern
    membranoproliferative GNb21 (56.8)
    endocapillary proliferative GNb13 (35.1)
    mesangial proliferative GN1 (2.7)
    membranous GN2 (5.4)
Crescentsc12 (32.4)
    focal10
    diffuse2
Interstitial inflammation: None/focal/diffused4/28/5 (10.8/75.7/13.5)
Tubular atrophy and interstitial fibrosis: None/mild/moderate/severee2/25/6/4 (5.4/67.6/16.2/10.8)
Arteriosclerosis and arteriolar hyalinosis: None/mild/moderate/severe9/16/11/1 (24.3/43.2/29.7/2.7)
Concurrent vascular amyloid1 (3)
  • aGN, glomerulonephritis.

  • bWith or without membranous features.

  • cFocal, <50% of glomeruli; diffuse, ≥50% of glomeruli.

  • dFocal <50% of cortical surface area; diffuse ≥50%.

  • eMild, 0 to 25% of cortical surface area; moderate, 26 to 50%; severe, >50%.