Table 8.

Clinical and pathologic differences among PGNMID, type 1 cryoglobulinemic glomerulonephritis, and IT

ParameterPGNMIDaType 1 Cryoglobulinemic Glomerulonephritis2IT3
Hypocomplementemia27%58%33%
Evidence of serum or urine monoclonal protein30%76%67%
Underlying MMVery rareVery rareVery rare
Underlying lymphoma/leukemiaVery rare33%17%
Renal insufficiency at presentation60%76%83%
Nephrotic syndrome53%38%50%
Intracapillary monocyte infiltration+++++
Intracapillary protein thrombiNoYesNo
Most common IgG subclassIgG3IgG3IgG1
Texture of deposits on EMGranularFocal annular-tubular or fibrillarMicrotubular with a diameter of 30 to 50 nm and hollow centers in parallel stacks
  • aData compiled from our cohort and the other cases reported in the literature.