Table 2.

Two-year risks for outcomes by treatment and CKD status (eGFR, ml/min per 1.73 m2) in patients with high-grade internal carotid artery stenosis (70 to 99%)

ParameterMedical Risk (%)(n = 126)a(n = 197)bSurgical Risk (%)(n = 91)a(n = 233)bRRR (%)Absolute Risk Difference (%; 95% CI)PInteraction Test (P)
Risk DifferenceRRR
Ipsilateral strokec
    eGFR <6031.65.682.326.0 (15.1 to 36.8)<0.0010.0180.051
    eGFR ≥6019.39.550.89.8 (1.9 to 17.7)0.047
Death (any cause)
    eGFR <609.49.7−3.2−0.3 (−11.1 to 10.5)0.940.830.78
    eGFR ≥605.94.916.91.0 (−4.4 to 6.4)0.59
Any stroke, MI, or vascular death
    eGFR <6040.717.557.023.2 (9.6 to 36.7)0.0160.070.26
    eGFR ≥6023.015.034.88.0 (−1.0 to 17.0)0.13
  • Medical and surgical groups were compared using a log-rank test. RRR, relative risk reduction.

  • aeGFR <60 ml/min per 1.73 m2.

  • beGFR ≥60 ml/min per 1.73 m2.

  • cTo provide a more conservative estimate of the benefits of endarterectomy, the outcome “ipsilateral stroke” includes any stroke and any death within 32 d of randomization (30 d postoperatively; median time from randomization to surgery was 2 d).