Table 3.

Two-year risks of outcomes by treatment and CKD status (eGFR, ml/min per 1.73 m2) in patients with moderate-grade ICA stenosis (50 to 69%)

ParameterMedical Risk (%)(n = 151)a(n = 266)bSurgical Risk (%)(n = 156)a(n = 270)bRRR (%)Absolute Risk Difference (%; 95% CI)PInteraction Test (P)
Risk DifferenceRRR
Ipsilateral strokec
    eGFR <6016.011.031.25.0 (−2.8 to 12.8)0.340.920.94
    eGFR ≥6013.69.133.14.5 (−1.0 to 9.9)0.15
Death (any cause)
    eGFR <6010.710.42.80.3 (−6.7 to 7.3)0.990.890.88
    eGFR ≥605.15.3−3.9−0.2 (−4.1 to 3.6)0.88
Any stroke, MI, or vascular death
    eGFR <6029.919.734.110.2 (−1.3 to 18.4)0.080.260.35
    eGFR ≥6021.518.215.33.3 (−2.7 to 11.1)0.45
  • Medical and surgical groups were compared using a log-rank test. RRR, Relative Risk Reduction.

  • aeGFR <60 ml/min per 1.73 m2.

  • beGFR ≥60 ml/min per 1.73 m2

  • cTo provide a more conservative estimate of the benefits of endarterectomy, the outcome “ipsilateral stroke” includes any stroke and any death within 32 d of randomization (30 d postoperatively; median time from randomization to surgery was 2 d).