Table 2.

Kidney function in Terc+/+, G1 Terc−/−, and G4 Terc−/− mice

ParameterCreatinine Clearance (ml/min)P, ANOVA
Terc+/+G1 Terc−/−G4 Terc−/−
Controls
    nonoperated0.145 ± 0.051 (n = 6)0.220 ± 0.024 (n = 5)0.110 ± 0.019 (n = 5)NS
    sham-operated0.197 ± 0.024 (n = 3)0.240 ± 0.031 (n = 3)0.147 ± 0.009 (n = 3)NS
Mice after IRI (15 min of ischemia to left kidney, right nephrectomy)
    day 70.130 ± 0.012 (n = 6)0.110 ± 0.023 (n = 7)0.065 ± 0.011 (n = 6)a0.06
    day 300.157 ± 0.017 (n = 6)0.151 ± 0.017 (n = 7)0.098 ± 0.006 (n = 6)b<0.05
  • aP = 0.06 for the comparison G4 Terc−/− vs. Terc+/+.

  • bP < 0.05 for the comparison G4 Terc−/− vs. Terc+/+.