Table 3.

Association of uromodulin concentrations at baseline and incident CKD case/control status in the FHS

ParameterOR (95% CI)P
MVa-adjusted model
    uromodulin concentrations1.55 (1.06 to 2.26)0.02
    uromodulin-to-creatinine ratio1.69 (1.02 to 2.79)0.04
MVa + baseline eGFR1.72 (1.07 to 2.77)0.03
MVa + baseline eGFR + ln(UACR)1.72 (1.06 to 2.79)0.03
Stratified analyses
    free of diabetes (n = 184)a1.76 (1.07 to 2.89)0.03
    age below median (n = 88)a1.53 (0.69 to 3.36)0.29
    age above median (n = 112)a1.62 (0.75 to 3.48)0.22
  • Data were analyzed using conditional logistic regression and are presented per 1-SD increase of ln(uromodulin) levels. MV, multivariable; OR, odds ratio.

  • aAnalyses are adjusted for systolic BP, hypertension treatment, diabetes, HDL cholesterol, smoking, and body mass index with age and gender matched by design, with the exception of diabetes adjustment for the analyses in individuals who were free of diabetes.