Table 1.

Histologic injury score in renal cortical tissue sections obtained before ischemia (baseline), immediately after 30 minutes of renal artery occlusion (ischemia), and after 30 minutes of recovery

ParameterTDZD-8
BaselineIschemiaRecovery
Sham −Sham +++
Proximal tubule
    dilation00102 to 31
    vacuolar changes0 to 10001 to 20
    brush border loss0 to 10113 to 41 to 2
    cell detachment00101 to 20 to 1
    nuclear condensation00000 to 10
Intratubular casts001 to 302 to 40
Interstitial edema000011
Leukocyte infiltration00001 to 20
Capillary edema00 to 1111 to 20
  • Injury was scored in 10 randomly selected fields in each tissue section; n = 6 animals.