Table 1.

Open reading frames capable of induction of cell death when overexpressed and with concomitant upregulation in the tubulointerstitial compartment in human DN biopsies (q ≤ 0.05)a

GeneSymbolFCLogFCq
EMP31.750.810.00
BASP11.620.700.00
PLP21.610.690.00
ARL6IP51.410.500.00
PTPLAD11.390.480.00
GNAS1.380.470.00
CYBA1.330.410.00
PPIB1.290.360.00
CLDN41.580.660.03
TMEM591.220.290.03
ITGB21.840.880.04
SSR41.310.390.04
  • FC, fold change over control; EMP3, epithelial membrane protein 3; PLP2, proteolipid protein 2 (colonic epithelium-enriched); ARL6IP5, ADP-ribosylation-like factor 6 interacting protein 5; PTPLAD1, protein tyrosine phosphatase-like A domain containing 1; GNAS, guanine nucleotide binding protein, alpha stimulating complex locus; CYBA, cytochrome b-245, alpha polypeptide; PPIB, peptidylprolyl isomerase B (cyclophilin B); CLDN4, claudin 4; TMEM59, transmembrane protein 59; ITGB2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); SSR4, signal sequence receptor, delta.

  • aData are presented as the fold-change increase in mRNA expression in DN as assessed by Affymetrix GeneChip.