Table 1.

Characteristics of study populations

NTNSC/PICMPK/PICMPK/HVJPaPb
Body weight, g33.28 ± 6.11534.66 ± 2.07436.20 ± 2.07830.31 ± 7.7000.2910.228
Spleen, g0.45 ± 0.1490.59 ± 0.2100.52 ± 0.1850.52 ± 0.1550.4270.511
Kidney, g0.21 ± 0.0390.22 ± 0.0220.22 ± 0.0180.23 ± 0.0590.3570.518
BUN, mg/dl29.66 ± 2.17126.90 ± 4.05719.18 ± 1.19924.77 ± 1.350<0.001<0.01
Proteinuria, mg/mg creatinine1.97 ± 0.2702.15 ± 0.5090.88 ± 0.1351.97 ± 0.315<0.05<0.05
  • NT, not treated; NSC/PIC, nonsilencing control siRNAs complexed with PIC nanocarriers; MPK/PIC, MAPK1 siRNAs complexed with PIC nanocarriers; MPK/HVJ, MAPK1 siRNAs encapsulated in HVJ-E.

  • aNT versus MPK/PIC.

  • bNSC/PIC versus MPK/PIC.