Table 1.

Functional and structural data from control and diabetic rats

ControlDiabetes
ShamAd-NullAd-S1Ad-S3
Blood glucose (mg/dl)95 ± 8581 ± 8a567 ± 20a576 ± 18a587 ± 9a
Body weight (g)283 ± 13209 ± 14a196 ± 7a235 ± 15a,b230 ± 14a,b
Creatinine clearance (ml/min/kg)1.42 ± 0.283.34 ± 0.26a3.23 ± 0.17a2.01 ± 0.14b2.12 ± 0.22b
Urinary albumin (mg albumin/mg creatinin)0.19 ± 0.049.72 ± 3.16a9.47 ± 1.48a2.76 ± 0.64a,b4.75 ± 1.07a,b
Kidney-to-body-weight ratio (g/kg)8.87 ± 0.4312.90 ± 0.57a13.41 ± 0.77a9.71 ± 1.07b9.42 ± 0.85b
Glomerular volume (μm3 × 106)0.45 ± 0.031.04 ± 0.06a1.00 ± 0.03a0.69 ± 0.04a,b0.61 ± 0.05a,b
  • aP < 0.05 versus control nondiabetic rats.

  • bP < 0.05 versus sham-operated diabetic rats.