Table 4.

Frequency of P-aHUS according to the type of complement dysregulation

PatientsNumber of PregnanciesP-aHUS (%)
CFH mutations (n = 23)a4910 (20%)
Mutations in SCR19-20 (n = 6)101 (10%)
Mutations in other SCR (n = 17)389 (24%)
CFI mutations (n = 8)263 (11%)
MCP mutations (n = 4)61 (17%)
C3 mutations (n = 3)72 (28%)
CFB mutations (n = 2)70 (0%)
More than one mutation (n = 4)b53 (60%)
No mutation (n = 10)153 (20%)
  • aThree patients with two mutations in CFH (SCR 9 and 19)—in C3/CFH and in MCP/CFH—were excluded from the analysis.

  • bPatients with two mutations in CFH (SCR 9 and 19)—in C3/CFH (patient 8), in MCP/CFH (P3), and in CFI/CFI (patient 4)