Table 1.

Characteristics of 21 patients with pregnancy-associated atypical hemolytic uremic syndrome

PatientNumber of Previous PregnanciesMedical HistoryAge at P-a HUS OnsetTime of Occurrence of aHUSHbPlts (g/L)LDH (IU/L)HaptoSchizSCr (mmol/L)TRTP-aHUS Outcome
1026M3 PP4.9445000<0.06+HDPE FFP CsGFR at 18 ml/min/1.73 m2 (M2); 33 ml/min/1.73 m2 (Y11)
2225D3 PP4.778NA<0.06+474PECR
31NS at M4 of P due to GNC3. ESRD due to TMA/GNC3 in father29W3 PPNA<70>750NANAHDNAESRD; Lost 2 RT due to TMA
4241W28 G7.5178630<0.1+84NoneCKD
5131W5 PP5.5310670<0.06+HDPE CsESRD
6141W3 PP5.51202469<0.06+HDPEESRD
70aHUS at the age of 18 years23W29 G7101573<0.06+500PEESRD
8NA23D10 PP6.51002373<0.06+HDNoneaESRD
91aHUS at the age of 30 years39W36 G8.92216580.08+353PE CsCKD
10027NANA<100>700NANAHDNAESRD
11023M4 PPbNA<100NA<0.08NAHDPE IVIgESRD
Lost 2 RT due to TMA
12023NANA<100NANANAHDPEESRD
13138W2 PP6.9782630<0.15+HDPEESRD
P at the age of 33 y
14022W1PP9.212>700<0.07+HDPE CsESRD
cardiomyopathy during P-aHUS
15027PPNA<100NANA+HDNAESRD
16135D15 PP6.754NA<0.01+HDPECKD
17130D3 PPNANANANANAHDPECardiomyopathy during P-aHUS
CKD; ESRD at Y3
18123M4 PPb6.8118NA<0.01+HDPE CsCKD; ESRD at M19
19130W2 PP63303200<0.01HDPEESRD
20124W3 PPNANANANANAHDNAESRD
aHUS recurrence after RT
213aHUS 2M before pregnancy324w G7.2108626NA+HDPECKD; Recurrence at Y1; ESRD at Y3
  • Pt, patient; Hb, hemoglobin; Plts, platelets; LDH, lactate dehydrogenase; Hapto, haptoglobin; Schizo, schizocytes; SCr, serum creatinin; KB, kidney biopsy; TRT, treatment; M, months; D, days; W, weeks; HD, hemodialysis; G, glomerular; A, arteriolar; CR, complete remission; RT, renal transplants; CKD, chronic kidney disease; NS, nephritic syndrome; GNC3, GN with exclusive glomerular C3 deposits; PrE, preeclampsia; PE, plasma exchange; FFP, fresh frozen plasma; NA, not available.

  • aRenal MRI showed cortical necrosis and PE was not started.

  • bUse of a contraceptive pill.