Table 2.

Nephron numbers in humans and associations with BP and birth weight

Age (years)Ethnicity (Location)GroupMean NglomΔNglomBirth WeightBPReference
0 to 1White/black (United Kingdom, Cuba, United States)IUGR versus NBW635,000 versus 903,000↓13 to 35%44,47,49
16 to 87White (Denmark)Normal population617,000 ± 155,00037
18 to 89White, black, Aboriginal (United States, Australia)White versus black versus Aboriginal855,183 ± 295,247 versus 921,708 ± 318,089 versus 733,484 ± 217,763↓ with ↓birth weight, ↑age, female, ↓height ↑VglomVariable45
34 to 87White (Denmark)Type 2 diabetes versus control673,000 ± 200,000 versus 670,000 ± 176,000NSNBW185
35 to 59White (Germany)Hypertensive versus normotensive746,468 ± 133,240 versus 1,402,360 ± 346,357↓47%41
30 to 65White (United States)Hypertensive versus normotensive747,727 ± 271,155 versus 894,339 ± 275,956↓16%NBW43,69
30 to 65BlackHypertensive versus normotensive912,480 ± 350,329 versus 931,463 ± 290,529NSNBW43,69
30 to 65(United States)White versus black861,879 ± 306,250 versus 917,789 ± 326,672NSNBW43
>18AustralianAboriginal versus non-Aboriginal683,174 ± 130,220 versus 885,318 ± 114,433↓30%LBW65
>18Australian AboriginalHypertensive versus normotensive631,321 ± 105,298 versus 843,324 ± 199,384↓30%LBW45
20 to 70African (Senegal)Normal population925,483 ± 225,42775
  • ΔNglom, change in nephron number between groups.