Table 1.

Placebo-controlled hypertension trials

TrialNLow BP AchievedComparison ArmsPrimary Results
SHEP44736143/68Diuretic-based regimen versus placebo36% RRR in stroke
STOP61627166/85β blocker and diuretic regimen versus placebo29% RRR in stroke
Syst-Eur34695153/77CCB-based regimen versus placebo42% RRR in stroke
Syst-China52394150/81CCB-based regimen versus placebo38% RRR in stroke
  • CCB, calcium channel blocker; RRR, relative risk reduction.