Table 3.

IRRs for CVD death, total mortality, CVD composite events, and ESRD for the AASK

Patient SubgroupESRD/CVD DeathESRD/CVD CompositeESRD/All Death
IRR (95% CI)PInteraction PIRR (95% CI)PInteraction PIRR (95% CI)PInteraction P
All patients5.01 (3.77 to 6.66)<0.0011.21 (1.02 to 1.43)0.0251.80 (1.48 to 2.17)<0.001
Age (years)
    ≤558.76 (5.66 to 13.55)<0.001<0.0011.89 (1.49 to 2.38)<0.001<0.0013.98 (2.92 to 5.42)<0.001<0.001
    >552.78 (1.90 to 4.07)<0.0010.72 (0.57 to 0.92)0.0090.89 (0.68 to 1.16)0.38
Baseline UP/Cr
    ≤0.222.35 (1.65 to 3.34)<0.001<0.0010.60 (0.47 to 0.76)<0.001<0.0010.89 (0.69 to 1.14)0.35<0.001
    >0.2212.18 (7.13 to 20.8)<0.0012.62 (2.01 to 3.41)<0.0013.92 (2.89 to 5.32)<0.001
Education
    high school or higher6.48 (4.35 to 9.63)<0.0010.031.59 (1.26 to 2.00)<0.001<0.0012.37 (1.84 to 3.06)<0.001<0.001
    lower than high school3.49 (2.28 to 5.34)<0.0010.82 (0.63 to 1.06)0.131.24 (0.93 to 1.64)0.14
Gender
    female4.37 (3.08 to 6.19)<0.0010.241.41 (1.08 to 1.84)0.010.142.60 (1.87 to 3.61)<0.0010.005
    male6.26 (3.90 to 10.05)<0.0011.09 (0.89 to 1.34)0.401.46 (1.17 to 1.84)0.001
Income
    <$15,0004.86 (3.26 to 7.26)<0.0010.581.07 (0.86 to 1.35)0.540.201.75 (1.33 to 2.30)<0.0010.66
    ≥$15,0005.86 (3.44 to 10.00)<0.001Reference1.38 (1.02 to 1.86)0.04Reference1.91 (1.39 to 2.62)<0.001Reference
    declined to answer4.21 (2.20 to 8.08)<0.0010.181.32 (0.89 to 1.96)0.160.871.74 (1.11 to 2.71)0.020.512
Mean baseline GFR
    >402.39 (1.66 to 3.45)<0.0010.430.56 (0.44 to 0.71)<0.001<0.0010.95 (0.73 to 1.23)0.68<0.001
    ≤4011.05 (6.70 to 18.20)<0.0012.89 (2.22 to 3.76)<0.0013.26 (2.49 to 4.28)<0.001
Preexisting CVD
    yes3.33 (2.37 to 4.67)<0.001<0.0010.95 (0.76 to 1.17)0.61<0.0011.40 (1.09 to 1.80)0.009<0.001
    no8.83 (5.33 to 14.64)<0.0011.58 (1.24 to 2.02)0.00022.38 (1.79 to 3.16)<0.001
  • Shown are unadjusted IRRs. Follow-up for CVD events and mortality was terminated at occurrence of ESRD. The interaction P value tested whether IRRs differed between the indicated subgroups.