Table 1.

Systemic parameters in age-matched male Sglt2−/− and WT mice

ParameterWTSglt2−/−
Body weight (g)30 ± 130 ± 1
Kidney weight (mg/g body wt)11.9 ± 0.311.9 ± 0.2
Heart rate (/min)576 ± 19579 ± 19
Hematocrit (%)42.4 ± 0.542.8 ± 0.5
Urine osmolality (mmol/kg)1849 ± 961488 ± 73a
Urine vasopressin (pmol/mmol creatinine)36 ± 339 ± 4
Plasma aldosterone (pg/ml)136 ± 1480 ± 12b
PRC (ng angiotensin I/ml per h)445 ± 39613 ± 61a
Plasma Na+ (mM)155 ± 1156 ± 2
Plasma K+ (mM)4.0 ± 0.14.0 ± 0.1
Plasma osmolality (mmol/kg)328 ± 2332 ± 2
  • Data are means ± SEM; n = 6 to 10 per group. PRC, plasma renin concentration.

  • aP < 0.05.

  • bP < 0.01.