Table 2.

Renal clearance experiments in age-matched male Sglt2−/− and WT mice

ParameterWTSglt2−/−
AE-glucose (nmol/min per g body wt)0.14 ± 0.0440.4 ± 10.7a
AE-Na+ (nmol/min per g body wt)3.8 ± 0.63.6 ± 0.6
AE-K+ (nmol/min per g body wt)6.1 ± 0.66.0 ± 0.6
AE-Cl (nmol/min per g body wt)3.2 ± 0.43.2 ± 0.7
AE-H2O (nl/min per g body wt)45 ± 1077 ± 10b
FE-glucose (%)0.26 ± 0.0463.6 ± 7.6a
FE-Na+ (%)0.36 ± 0.030.36 ± 0.05
FE-K+ (%)17.7 ± 1.518.5 ± 2.3
FE-Cl (%)0.42 ± 0.050.44 ± 0.11
FE-H2O (%)0.62 ± 0.091.20 ± 0.20a
  • Data are means ± SEM; n = 6 to 8 per group. AE, absolute renal excretion; FE, fractional renal excretion.

  • aP < 0.01.

  • bP < 0.05.