Table 3.

Baseline patient characteristics by the daily prescribed dosage of digoxin on the 90th day of long-term dialysis

CharacteristicDosage of Digoxin (μg/d)P
<55.055.0 to 62.562.6 to 120.0>120.0
N145012382731446
Demographic
    age (years)70.2 (0.3)70.6 (0.3)71.1 (0.6)67.3 (0.3)<0.0001
    male gender (%)56.8 (0.7)59.6 (0.7)62.9 (0.7)61.8 (0.7)0.03
    race (%)
        black22.3 (0.6)21.3 (0.6)14.3 (0.5)27.2 (0.6)<0.0001
        other6.2 (0.3)7.0 (0.3)7.3 (0.3)7.6 (0.3)
        white71.4 (0.6)71.6 (0.6)78.4 (0.6)65.2 (0.7)
Access (%)
    AVF20.0 (0.6)19.4 (0.5)20.1 (0.6)19.4 (0.5)0.52
    catheter54.8 (0.7)58.6 (0.7)59.0 (0.7)57.0 (0.7)
    graft19.9 (0.6)18.2 (0.5)17.2 (0.5)18.7 (0.5)
    unknown5.4 (0.3)3.8 (0.2)3.7 (0.2)4.9 (0.3)
Hemodynamic
    SBP (mmHg)136.1 (0.5)137.4 (0.5)137.0 (1.1)138.8 (0.4)0.002
    DBP (mmHg)67.1 (0.2)67.3 (0.2)66.9 (0.5)68.8 (0.2)<0.0001
    interdialytic weight gain (kg)2.40 (0.02)2.40 (0.02)2.40 (0.10)2.50 (0.02)0.03
    weight (kg)72.8 (0.5)74.5 (0.6)73.7 (1.0)77.6 (0.6)<0.0001
Comorbidity
    Charleson index5.20 (0.05)5.10 (0.05)5.10 (0.10)5.20 (0.04)0.30
    diabetes (%)67.5 (0.7)68.5 (0.6)67.0 (0.7)72.6 (0.6)0.01
Laboratory
    hemoglobin (g/dl)11.40 (0.03)11.40 (0.03)11.50 (0.07)11.30 (0.03)0.18
    albumin (g/dl)3.50 (0.01)3.50 (0.01)3.50 (0.02)3.50 (0.01)0.52
    potassium (mEq/L)4.50 (0.01)4.50 (0.01)4.50 (0.03)4.50 (0.01)0.09
    calcium (mg/dl)8.80 (0.02)8.80 (0.02)8.80 (0.04)8.80 (0.02)0.03
    creatinine (mg/dl)5.30 (0.06)5.40 (0.06)5.30 (0.10)5.40 (0.06)0.56
Treatment parameters
    time (hours)3.50 (0.01)3.60 (0.01)3.60 (0.03)3.60 (0.01)0.64
    dialysate potassium (mEq/L)2.43 (0.02)2.40 (0.02)2.45 (0.03)2.37 (0.01)0.006
    dialysate calcium (mEq/L)2.60 (0.01)2.60 (0.01)2.60 (0.02)2.60 (0.01)0.41
Medications
    EPO (1000 U per sessions)7.6 (0.1)7.4 (0.1)7.4 (0.4)7.5 (0.1)0.91
    antiplatelet (%)42.8 (0.7)46.7 (0.7)48.7 (0.7)42.4 (0.7)0.03
    statin (%)35.0 (0.7)38.2 (0.7)39.9 (0.7)37.7 (0.7)0.21
    β blocker (%)60.2 (0.7)59.2 (0.7)59.3 (0.7)60.6 (0.7)0.89
    ACEI or ARB (%)46.1 (0.7)45.3 (0.7)43.6 (0.7)44.5 (0.7)0.79
  • Data are means (SE). A total of 142 patients who were on digoxin did not have a dosage documented.

  • Legend: ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; AVF, arteriovenous fistula; DBP, diastolic blood pressure; SBP, systolic blood pressure; EPO, Epogen.