Table 2.

Association of decreased GFR (<60 ml/min per 1.73 m2) by cystatin C and creatinine with adverse events in MESA and CHS

MESACHS
nHR (95% CI)nHR (95% CI)
Demographic AdjustedaFully AdjustedbDemographic AdjustedaFully Adjustedb
All-cause mortalityc
    GFR not decreased57591.00 (ref)1.00 (ref)36391.00 (ref)1.00 (ref)
    decreased GFRcreat only6140.76 (0.48, 1.20)0.80 (0.50, 1.26)6051.10 (0.98, 1.22)1.09 (0.98, 1.21)
    decreased GFRcys only1073.43 (1.96, 5.98)3.23 (1.84, 5.67)2271.94 (1.67, 2.25)1.78 (1.53, 2.08)
    decreased GFR both2691.97 (1.31, 2.96)1.93 (1.27, 2.92)6891.96 (1.78, 2.16)1.74 (1.58, 1.93)
Cardiovascular diseased
    GFR not decreased1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
    decreased GFRcreat only1.18 (0.78, 1.78)1.22 (0.80, 1.85)1.13 (0.99, 1.29)1.05 (0.92, 1.20)
    decreased GFRcys only2.22 (1.13, 4.39)1.92 (0.97, 3.82)1.83 (1.52, 2.21)1.52 (1.26, 1.84)
    decreased GFR both2.07 (1.32, 3.24)1.67 (1.06, 2.63)1.86 (1.65, 2.09)1.46 (1.29, 1.65)
Heart failuree
    GFR not decreased1.00 (ref)1.00 (ref)
    decreased GFRcreat only1.08 (0.91, 1.27)0.99 (0.84, 1.18)
    decreased GFRcys only2.12 (1.68, 2.66)1.69 (1.33, 2.13)
    decreased GFR both1.91 (1.64, 2.23)1.43 (1.22, 1.67)
Kidney failuref
    GFR not decreased1.00 (ref)1.00 (ref)
    decreased GFRcreat only2.67 (1.03, 6.90)2.60 (1.00, 6.75)
    decreased GFRcys only7.69 (2.78, 21.25)6.14 (2.18, 17.29)
    decreased GFR both30.95 (17.0, 56.34)23.82 (12.68, 44.76)
  • ref, referent group.

  • aAdjusted for age, race, and gender.

  • bAdjusted for age, race, gender, diabetes, hypertension, LDL, HDL, CRP, and prevalent CVD for CHS (persons with baseline CVD were excluded for incident CVD analyses).

  • c223 deaths for MESA and 3345 deaths for CHS.

  • d212 events for MESA and 2249 events for CHS.

  • e1407 events for CHS.

  • f84 events for CHS.