Table 2.

Intra-assay, intraobserver reproducibility of visual assessment of fibrosis

Definition of FibrosisObserverAssay DayMean (%)SD (%)Minimum (%)Maximum (%)Average DifferenceaR2b
% Fibrous area
11462915907.3 ± 7.20.90
23928390
21272327011.0 ± 8.90.67
23125575
3138284857.7 ± 6.40.88
23425480
% Fibrotic cortex
115232610013.1 ± 14.50.62
24729588
21443839511.7 ± 16.40.75
247413100
3150355959.3 ± 9.20.88
24432492
  • Three observers scored 15 biopsies stained and evaluated on two different days, according to two definitions of % fibrosis (see Concise Methods).

  • aMean absolute difference ±SD (as in Table 1).

  • bCoefficient of determination, as in Table 1, all P < 0.0001.