Table 6.

Over-represented KEGG pathways (P < 0.01) in transbands on Chrs 1, 4, 15, and 17

PathwayPNo. of GenesGenes
Chr 1
    aminoacyl-tRNA biosynthesis1.79 × 10−414 (37)Aars2, Dars, Dars2, Eprs, Hars2, Iars, Iars2, Lars2, Sars, Tars, Tars2, Wars, Wars2, Yars
    cell cycle0.00127 (174)Anapc1, Anapc4, Atm, Ccna2, Ccnd1, Cdc16, Cdc23, Cdk2, Cdk4, Cdkn1, Cdkn2c, Check2, Cul1, Mad2l1, Mad2l2, Mcm2, Mcm3, Mcm6, Mdm2, Orcsl, Orc3l, Orc4l, Orc6l, Pik1, Smc1a, Trp53
    ECM-receptor interaction0.00121 (79)Agm, Chad, Col2a1, Col3a1, Col4a1, Col4a2, Col4a4, Fndc3a, Gp5, Hmmr, Itga1, Itga3, Itga6, Itgav, Itgb, Lamc3, Npnt, Sdc3, Spp1, Sv2a, Sv2c
    N-glycan degradation0.0027 (15)Ag, Hexa, Lct, Manba, Neu1, Neu2, Neu3
    alanine and aspartate metabolism0.00311 (33)ars2, Acy3, Adsl, Adss, Asl, Ass1, Dars, Dars2, Gad1, Pdha1, Pet112l
    leukocyte transendothelial migration0.00724 (106)Actn2, Actn3, Cdh5, Cldn14, Cldn6, Cldn9, Ctnnb1, Ctnndl, Cybb, Ezr, Gnai2, Itgb1, Mmp2, Ncf2, Ncf4, Ocln, Pecam1, Pik3r3, Plcg2, Rhoa, Rock1, Thy1, Vav2, Vcam1
    DNA replication0.00912 (33)Fen1, Mcm2, Mcm3, Mcm7, Pola1, Pola2, Pold3, Prim1, Prim2, Rcf1, Rcf3, Rpa1
Chr 4
    glutathione metabolism2.45 × 10−414 (35)Ggt7, Gpx3, Gsr, Gsta3, Gsta4, Gstk1, Gstm1, Gsto1, Gsto2, Gstt1, Gstt2, Idh1, Mgst3, Txndc12
    glycine, serine, and threonine metabolism0.00115 (42)Abp1, Akr1c13, Akr1c6, Akr1e1, Chdh, Gars, Gatm, Gldc, Maoa, Maob, Phgdh, Pisd, Sars, Shmt2, Tarsl2
    bisphenol A degradation0.0015 (7)Akr1c13, Akr1c6, Akr1e1, Pon2, Pon3
    fatty acid metabolism0.00214 (41)Acaa2, Acadm, Acads, Acat1, Acox3, Acsl1, Acsl5, Acsl6, Aldh3a2, Cpta1a, Cyp4a10, Cyp4a12b, Dci, Hsd17b10
    glycan structures, degradation0.00210 (25)Arsb, Fuca1, Fuca2, Galns, Gib1, Gusb, Hgsnat, Hyal1, Man2b1
    arginine and proline metabolism0.00311 (30)Aldh4a1, Arg2, Asi, Ass1, Ckmt1, Gatm, Glud1, Lcmt1, Oat, P4 ha2, Prodh
    urea cycle and metabolism of amino groups0.00310 (26)Abp1, Acy1, Aldh3a2, Arg2, Asl, Ass1, Gatm, Maoa, Maob, Srm
    glycerophospholipid metabolism0.00716 (57)Ard1a, Cris1, Dgkb, Dgkq, Dgkz, Etnk1, Gnpat, Gpd1, Gpd2, Lypla2, Pcyt1a, Pisd, Pla2g6, Pld2, Ppap2c, Ptdss1
    glycosaminoglycan degradation0.0076 (13)Arsb, Galns, Gib1, Gusb, Hgsnat, Hyal1
    renin-angiotensin system0.0088 (17)Ace, Agt, Agtra1, Anpep, Lnpep, Mas1, Mme, Ren1
Chr 15
    nitrogen metabolism2.34 × 10−59 (20)Amt, Asna, Car12, Car14, Car5a, Car5b, Car6, Gls, Gls2
    fatty acid metabolism3.40 × 10−513 (41)Acaa1b, Acadvl, Acox1, Adh1, Adh5, Aldh2, Aldh7a1, Cpt1b, Cyp4a10, Dci, Gcdh, Hsd
    drug metabolism, cytochrome P4502.40 × 10−416 (68)Adh1, Adh5, Cyp2c39, Cyp2c44, Cyp2d22, Cyp2d9, Fmo5, Gsta2, Gstk1, Gstm2, Gstm7, Gsto2, Gstp1, Gstl2, Mgst3, Ugt2a3
    metabolism of xenobiotics by P4500.00114 (62)Adh1, Adh5, Cyp2c39, Cyp2c44, Dhdh, Gsta2, Gstk1, Gstm2, Gstm7, Gsto2, Gstp1, Gstl2, Mgst3, Ugt2a3
    glutathione metabolism0.0039 (35)Gtg1, Gsta2, Gstk1, Gstm2, Gstm7, Gsto2, Gstp1, Gstl2, Mgst3
    biosynthesis of unsaterated fatty acids0.0038 (29)Acaa1b, Acot2, Acot5, Acot8, Acot9, Acox1, Elov16, Fads2
    butanoate metabolism0.0049 (36)Abat, Akr1c13, Aldh2, Aldh7a1, Hmgcl, Hmgcs2, Hsd17b10, Hsd17b4, Pdha1
    alanine and aspartate metabolism0.0078 (33)Aars, Abat, Adssl1, Agxt2, Asns, Aspa, Ddo, Pdha1
Chr 17
    antigen processing and presentation3.10 × 10−621 (79)B2m, H2-Ab1, H2-DMa, H2-DMb1, H2-DMb2, H2-Ea, H2-Eb1, H2-K1, H2-L, H2-M1, H2-M3, H2-Q1, H2-Q1, H2-Q8, H2-Q9, H2-T10, H2-T22, H2-T23, Hspa1l, Nfya, Tap1
    cell adhesion molecules2.59 × 10−528 (139)Cdh3, Cdh4, Cldn11, Cldn23, Cldn7, H2-Ab1, H2-DMa, H2-DMb1, H2-DMb2, H2-Ea, H2-Eb1, H2-K1, H2-L, H2-M1, H2-M3, H2-Q1, H2-Q1, H2-Q8, H2-Q9, H2-T10, H2-T22, H2-T23, Jam2, Negr1, Nrxn3, Ptprf, Sele, Vcam1
  • The number of genes present in the transband is given, and the number of genes in the pathway represented on the microarray is indicated in parentheses. The MGI symbols (http://www.informatics.jax.org/) for the genes involved in each pathway on the transband are given.