Table 5.

Slope of regression line between eGFR and percentage of fibrosis

TechniqueSirius Red UnpolarizedCollagen IIITrichrome-PASVisual % FibrousVisual % Abnormal
CKD-EPI (ml/min per 1.73 m2)−2.5−2.8−1.0−1.1−0.9
MDRD (ml/min per 1.73 m2)−0.5−1.1−1.2−0.3−0.5
Cockcroft-Gault (ml/min)−2.3−2.8−3.0−1.2−1.0
  • Slope is change in eGFR (ml/min) per 1% change in fibrosis, by least squares fit for the fibrosis measurements in Table 4. For example, for collagen III a 10% increase in fibrosis is associated with a 28 ml/min decrease in eGFR using the Cockcroft-Gault formula.