Table 1.

Potential clinical relevance of WNK kinases in nephrology

Mutations in WNK1 or WNK4 cause familial hyperkalemic hypertension
Salt retention caused by aldosterone or angiotensin II is mediated via WNK kinases
Polymorphisms in the WNK1 and WNK4 genes are associated with hypertension
A low potassium diet may predispose to hypertension because it increases the WNK1/KS-WNK1 ratio leading to more salt reabsorption
WNK4 mediates the antinatriuretic effects of insulin in diabetes mellitus
The WNKs are promising candidates for development of new anti-hypertensive drugs