Table 1.

Mean blood pressure and albuminuria in TRPC6 wild-type and knockout mice

Wild-type MiceKnockout MiceP
MAP (telemetry; mmHg)
    number (n)56
    prior to Ang II121 ± 15.75119 ± 13.17NS
    day 7142 ± 20.78153 ± 21.21NS
    day 14150 ± 22.31154 ± 21.25NS
    day 21160 ± 26.48162 ± 27.34NS
    day 28163 ± 20.68160 ± 23.26NS
SBP (tail cuff; mmHg)
    number (n)78
    prior to Ang II115 ± 10.26109 ± 9.72NS
    day 7155 ± 11.36168 ± 20.51NS
    day 14174 ± 32.39172 ± 30.93NS
    day 21183 ± 20.27195 ± 20.42NS
    day 28195 ± 16.72189 ± 29.83NS
Albuminuria (mcg/day)
    number (n)1418
    prior to Ang II25 ± 12.9730 ± 17.49NS
    week 1420 ± 249.32337 ± 261.81NS
    week 21151 ± 452.43653 ± 400.040.004
    week 31414 ± 538.69963 ± 577.460.04
    week 41760 ± 499.891287 ± 895.53NS
  • The values are expressed as the means ± SD. MAP, mean arterial pressure; SBP, systolic blood pressure; NS, not significant.