Table 3.

Competing-risk model of variables associated with the cumulative incidence of death prior to ESRD in patients with type 1 diabetes and macroalbuminuria from the FinnDiane cohort. For graphical interpretation, see Figure 3

Baseline Parameter	Subhazard Ratio	[95% CI]	P > t
Age (years)	1.05	1.02 to 1.07	0.001
Total cholesterol (mmol/L)	1.75	1.17 to 2.61	0.007
Macrovascular disease (yes/no) × age	1.01	1.00 to 1.03	0.03
eGFR (standardized)^a	2.12	1.25 to 3.58	0.005
eGFR (orthogonalized basis)^a	1.59	0.92 to 2.76	0.09
eGFR (orthogonalized basis)^a	0.56	0.36 to 0.88	0.01

↵^aeGFR was parameterized as a 3rd-degree (cubic) regression spline with knots at 32.1 and 52.9. The parameterization of the spline is thus: a spline with m knots has m + 1 so-called basis functions (and similar degrees of freedom) and these basis functions are orthogonalized to have mean 0 and SD 1 and to be uncorrelated.²⁸