Competing-risk model of variables associated with the cumulative incidence of death prior to ESRD in patients with type 1 diabetes and macroalbuminuria from the FinnDiane cohort. For graphical interpretation, see Figure 3
Baseline Parameter | Subhazard Ratio | [95% CI] | P > t |
---|---|---|---|
Age (years) | 1.05 | 1.02 to 1.07 | 0.001 |
Total cholesterol (mmol/L) | 1.75 | 1.17 to 2.61 | 0.007 |
Macrovascular disease (yes/no) × age | 1.01 | 1.00 to 1.03 | 0.03 |
eGFR (standardized)a | 2.12 | 1.25 to 3.58 | 0.005 |
eGFR (orthogonalized basis)a | 1.59 | 0.92 to 2.76 | 0.09 |
eGFR (orthogonalized basis)a | 0.56 | 0.36 to 0.88 | 0.01 |
↵aeGFR was parameterized as a 3rd-degree (cubic) regression spline with knots at 32.1 and 52.9. The parameterization of the spline is thus: a spline with m knots has m + 1 so-called basis functions (and similar degrees of freedom) and these basis functions are orthogonalized to have mean 0 and SD 1 and to be uncorrelated.28