Baseline Parameter | Subhazard Ratio | [95% CI] | P > t |
---|---|---|---|

Age (years) | 1.05 | 1.02 to 1.07 | 0.001 |

Total cholesterol (mmol/L) | 1.75 | 1.17 to 2.61 | 0.007 |

Macrovascular disease (yes/no) × age | 1.01 | 1.00 to 1.03 | 0.03 |

eGFR (standardized)^{a} | 2.12 | 1.25 to 3.58 | 0.005 |

eGFR (orthogonalized basis)^{a} | 1.59 | 0.92 to 2.76 | 0.09 |

eGFR (orthogonalized basis)^{a} | 0.56 | 0.36 to 0.88 | 0.01 |

↵

^{a}eGFR was parameterized as a 3rd-degree (cubic) regression spline with knots at 32.1 and 52.9. The parameterization of the spline is thus: a spline with*m*knots has*m*+ 1 so-called basis functions (and similar degrees of freedom) and these basis functions are orthogonalized to have mean 0 and SD 1 and to be uncorrelated.^{28}