Table 1.

Characteristics of patients with T1D and macroalbuminuria according to subcohort defined by date of enrollment

CharacteristicSubcohortP
1991 to 1995 (n = 113)1996 to 2000 (n = 112)2001 to 2004 (n = 198)
Men (%)53.153.653.51.0
Age (years)34.1 ± 5.737.6 ± 7.241.8 ± 9.7<0.0001
Age at T1D diagnosis (years)11.5 ± 6.711.6 ± 7.215.3 ± 8.9<0.0001
T1D duration (years)22.6 ± 6.726.0 ± 8.226.5 ± 8.90.0001
Duration of care at Joslin (years)17.4 ± 8.821.2 ± 10.718.0 ± 12.00.05
HbA1c (%)9.1 ± 1.69.4 ± 1.98.7 ± 1.60.01
Body mass index (kg/m2)25.1 ± 4.325.3 ± 4.827.6 ± 6.4<0.0001
Patients using lipid-lowering drugs (%)8.010.742.4<0.0001
Total cholesterol (mg/dl)228 ± 64212 ± 51202 ± 49<0.0001
Current smokers (%)28.126.420.70.30
Systolic blood pressure (mmHg)137 ± 20134 ± 18131 ± 170.006
Diastolic blood pressure (mmHg)81 ± 1080 ± 976 ± 10<0.0001
Patients using ACE-I or ARB (%)55.862.581.8<0.0001
ACR (mg/g)967 (526 to 1667)736 (442 to 1310)778 (465 to 1795)0.15
eGFR (ml/min)70 ± 3573 ± 3760 ± 300.005
  • The data are the means ± SD or percent. eGFR, MDRD estimate of glomerular filtration rate based on serum creatinine.