Table 2.

Risk of ESRD and pre- or post-ESRD mortality in patients with T1D and macroalbuminuria according to subcohort defined by date of enrollment

Subcohort
1991 to 1995 (n = 113)1996 to 2000 (n = 112)2001 to 2004 (n = 198)
First 6 years of follow-up
    number of person-years517561864
    incidence rate of ESRD per 100 person-years
        in patients using ACE-I/ARB6.2 (20)6.1 (21)6.4 (46)
        in patients not using ACE-I/ARB6.5 (16)4.9 (11)6.3 (9)
        in all patients6.3 (36)5.7 (32)6.4 (55)
    age at ESRD onset (years)39 (36, 46)42 (38, 46)46 (38, 52)
    T1D duration at ESRD onset (years)24 (21, 30)30 (22, 37)28 (23, 37)
All years of follow-upa
    number of person-years1175888902
    incidence rate of ESRD per 100 person-years5.3 (62)5.5 (49)6.8 (61)
    pre-ESRD mortality rate per 100 person-years0.8 (9)1.1 (10)1.1 (10)
    number of person-years332180135
    post-ESRD mortality rate per 100 person-years10.3 (34)10.6 (19)12.6 (17)
  • The data are the incidence rates (number of events) or medians (25th, 75th percentiles).

  • aFollow-up of the cohort of 423 patients through 2008 gave observation intervals with a median (25th, 75th percentiles) of 6.9 (5.2, 12.0) years and 3612 person-years of observation (2966 person years with macroalbuminuria and 646 person-years after ESRD onset).