Table 1.

BMP1–3 (ng/ml) values in human and rat plasma

AgenBMP1–3
Human
    healthy blood volunteers20 to 65 years (5 men and 5 women)1051 ± 4
    CKD patients43 to 68 years (7 men and 3 women)1079 ± 9a
Male rat
    healthy control2.5 months12108 ± 16
    CKD control2.5 months12202 ± 31b
    CKD + BMP1–3 antibody (1 μg/kg)2.5 months10152 ± 29
    CKD + BMP1–3 antibody (5 μg/kg)2.5 months1063 ± 11c
    CKD + BMP1–3 antibody (15 μg/kg)2.5 months88 ± 3c
  • Ten milliliters of human plasma were collected, purified, and analyzed as indicated in the methods. Five milliliters of rat blood were collected from the same animals within 3 days and pooled, purified, and analyzed as described. Results are shown as mean ± SD.

  • aP < 0.05 versus healthy volunteers;

  • bP < 0.01 versus control rats;

  • cP < 0.05 versus CKD control rats.