Table 2.

Results of the piecewise proportional hazards model for the relationship between dialysis modality and death

Adjustedb Time dependenta HR [95% CI]Univariate Time dependenta HR [95% CI]Adjustedb Time dependenta HR [95% CI]Adjustedb Time averagec HR [95% CI]
Overalld
    PD1.0PD1.01.01.0
    HD1.0 [1.0, 1.1]HD-CVC1.7 [1.6, 1.7]1.2 [1.1, 1.2]1.2 [1.1 1.2]
HD-AVF/AVG1.1 [1.0, 1.1]0.8 [0.8, 0.9]0.8 [0.8,0.9]
Year 1
    PD1.0PD1.01.01.0
    HD1.5 [1.4,1.7]HD-CVC2.7 [2.4, 2.9]1.8 [1.6, 1.9]1.6 [1.5, 1.8]
HD-AVF/AVG1.1 [1.0, 1.3]0.9 [0.8, 1.1]0.9 [0.8,1.1]
Year 2
    PD1.0PD1.01.01.0
    HD1.0 [0.9, 1.1]HD-CVC1.5 [1.4, 1.6]1.1 [1.0, 1.2]1.4 [1.3, 1.5]
HD-AVF/AVG0.9 [0.8, 1.0]0.8 [0.7, 0.9]0.8 [0.8,0.9]
Year 3
    PD1.0PD1.01.01.0
    HD0.8 [0.7, 0.9]HD-CVC1.2 [1.1, 1.4]0.9 [0.8, 1.0]1.2 [1.2, 1.3]
HD-AVF/AVG0.9 [0.8, 1.0]0.7 [0.6, 0.8]0.8 [0.7, 0.9]
Year 4
    PD1.0PD1.01.01.0
    HD0.8 [0.7,1.0]HD-CVC1.3 [1.1, 1.5]0.9 [0.8, 1.0]1.2 [1.1, 1.2]
HD-AVF/AVG1.1 [0.9, 1.3]0.8 [0.7, 1.0]0.8 [0.7,0.9]
Year 5
    PD1.0PD1.01.01.0
    HD0.8 [0.7, 0.9]HD-CVC1.2 [1.1, 1.5]0.9 [0.7, 1.0]1.2 [1.1,1.2]
HD-AVF/AVG1.1 [0.9, 1.3]0.8 [0.7, 1.0]0.8 [0.8,0.9]
  • aTime-dependent hazard ratios within each year were used to assess annual mortality risk.

  • bIntention to treat, adjusted for age, race, gender, era of dialysis initiation, end-stage renal disease comorbidity index, primary renal diagnosis, serum albumin, estimated glomerular filtration rate, province of treatment, and late referral.

  • cTime-averaged hazard ratios from a proportional hazards model were used to assess the cumulative treatment effect from day 0 through the end of years 1 to 5, respectively.

  • dOverall model and time average models constructed using 29,647 subjects using proportional hazards model, remainder of time-dependent models using nonproportional hazards model.