Table 1.

Frequency of allele carriers among patient groups stratified by race and serotype

Controla (%)PR3-ANCAMPO ANCA
(%)Odds Ratio95% CIP(%)Odds Ratio95% CIP
(A) African Americanb
    DRB1*1518 (17%)15 (94%)73.39.1 to 591.02.3 × 10−9 e3 (12%)0.70.2 to 2.50.76e
    DRB1*0417 (16%)4 (25%)1.70.5 to 6.10.47e4 (16%)1.00.3 to 3.31.00e
    DRB1*160 (0)0 (0)2 (8%)1.11.0 to 1.20.04
(B) Caucasianc
    DRB1*1546 (17%)23 (31.1)2.21.2 to 4.00.007d4 (18%)1.10.4 to 3.40.77e
    DRB1*144 (2%)6 (8.1)5.91.6 to 21.60.008d1 (5%)3.20.3 to 30.00.32d
    DRB1*0357 (21%)23 (32.1)1.71.0 to 3.00.065 (23%)1.10.4 to 3.20.79
    DRB1*1134 (13%)12 (16.2)1.40.7 to 2.80.41 (5%)0.30.1 to 2.60.49
  • aCommunity-based control frequencies obtained from the Healthy Organ Donor- North Carolina Services.

  • bControl, n = 106; PR3-ANCA, n = 16; MPO ANCA, n = 25.

  • cControl, n = 273; PR3-ANCA, n = 74; MPO ANCA, n = 22.

  • dχ2 test.

  • eFisher exact test.