Table 5.

Antigen reactivities specific to all cohort 2 and 3 patients with TG

Accession NumberProteinKnown FunctionKnown Tissue Expression Patterna
BC005982.1PPIAAlso called cyclophilin A, PPIA is the molecular target of cyclosporine A involved in T cell activation. The cyclosporine-cyclophilin A complex inhibits a calcium/calmodulin-dependent phosphatase, calcineurin, the inhibition of which is thought to suppress organ rejection by halting the production of the pro-inflammatory molecules TNFα and interleukin-2. PPIs also catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins.55Kidney, vascular smooth muscle cells, fibroblasts macrophages53,56
BC006423.1AURKAThe cell cycle-regulated kinase appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation; Aurora A dysregulation has been associated with a high occurrence of cancer.35,36Kidney, liver, but highest expression in lymphoblasts and endothelial cells, colon adenocarcinoma56
NM018441.2PECRPECR is a peroxisomal NADPH-specific trans-2-enoyl-CoA reductase that catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA.33,57CD4/CD8 T cells, B cells, dendritic cells, endothelial cells, smooth muscle, kidney, liver, adipocytes56