Table 3.

Hazard ratio (95% CI) for the composite outcome of initiation of chronic dialysis or death according to quartiles of baseline plasma FGF-23 concentrations

ModelsQ1 ≤ 216 RU/mlQ2 217–380 RU/mlQ3 381–945 RU/mlQ4 >946 RU/ml
Model 11.001.70 (1.37–2.10)2.92 (2.36–3.61)4.43 (3.57–5.49)
Model 21.001.26 (1.01–1.57)1.66 (1.31–2.11)2.32 (1.80–2.98)
Model 31.001.26 (1.01–1.58)1.65 (1.30–2.10)2.30 (1.78–2.96)
  • Model 1 included adjustment for age, gender, race. Model 2 included adjustment for covariates in Model 1 plus smoking, alcohol intake, diabetes, hypertension, cardiovascular disease, Carlson score, body mass index, systolic and diastolic BP, homocysteine, folate, vitamin B12, treatment assignment, hemoglobin, MDRD-GFR, as well as concentrations of serum albumin, calcium, phosphorus, 25-hydroxyvitamin D, 1,25 dihydroxyvitamin D, intact parathyroid hormone, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides. Model 3 included adjustment for covariates in Model 2 plus the use of angiotensin converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, aldosterone antagonists, lipid-lowering agents, aspirin, anticoagulants, anti-arrhythmic drugs and sevelamer. Quartile 1 is the reference group in all models.