Table 2.

Stepwise conditional association analyses of APOL1 and MYH9 variants in the combined cohort of HIVAN and FSGS (65 cases and 74 controls)

ChrSNPTested AlleleConditioning SNP
Not Conditionedrs60910145rs60910145 and rs71785313
ORaPbORaPbORaPb
22rs73885319G2.71 (1.64 to 4.48)8.1 × 10−5***1.34 (0.21 to 8.52)0.76 (NS)1.74 (0.26 to 11.8)0.57 (NS)
22rs60910145G2.82 (1.70 to 4.68)4.8 × 10−5***
22rs71785313Del2.09 (1.13 to 3.88)0.018*3.71 (1.80 to 7.66)3.9 × 10−4***
22rs11912763A2.99 (1.73 to 5.15)6.0 × 10−5***2.03 (1.01 to 4.09)0.048*1.95 (0.94 to 4.03)0.074 (NS)
22rs4821481C1.83 (1.06 to 3.16)0.029*0.90 (0.48 to 1.67)0.73 (NS)1.57 (0.75 to 3.26)0.23 (NS)
22rs5750250G2.61 (1.55 to 4.40)2.6 × 10−4***0.57 (0.33 to 1.01)0.055 (NS)0.98 (0.49 to 1.94)0.95 (NS)
  • Chr, chromosome; SNP, single-nucleotide polymorphism; NS, not significant.

  • aOR corresponds to the conditioned odds ratio per one copy of the minor allele.

  • bP value corresponds to the conditional test of association under additive allele coding.

  • *P < 0.05;

  • ***P < 0.001.