Table 1.

Blood pressure and excretory function in CD-KO and control mice

Physiological ParametersControl Mice (n = 7 to 14)CD-KOs (n = 7 to 14)
BaselineWater DeprivationBaselineWater Deprivation
Mean arterial pressure (mmHg)120 ± 6 (n = 6)130 ± 6 (n = 6)a121 ± 5 (n = 6)134 ± 6 (n = 6)a
Water intake (ml/day)4.2 ± 0.8 (n = 13)N/A4.2 ± 1.0 (n = 13)N/A
Osmolar excretion rate (mOsmol/kg H2O * ml/h)133.1 ± 8.9 (n = 13)128.1 ± 11.34 (n = 13)138.7 ± 7.3 (n = 13)163.5 ± 11.6 (n = 13)b
Urinary sodium excretion (mM/24 h)0.25 ± 0.03 (n = 13)0.14 ± 0.02 (n = 13)c0.29 ± 0.02 (n = 13)0.16 ± 0.03 (n = 13)c
  • Shown are the baseline characteristics in CD-KO and control mice under baseline conditions and after 18 hours of water deprivation. The data are presented as the means ± SEM. N/A, not applicable.

  • aP < 0.05 versus baseline control and baseline CDKO.

  • bP < 0.05 versus water deprivation control.

  • cP < 0.01 versus baseline control and baseline CD-KO.