Table 1.

Different cell population in vehicle- and nutlin-3a-treated MRL-Faslpr mice

VehicleNutlin-3a
Spleen (cells/million)
    Total number of cells460.61 ± 57.15291.21 ± 43.55a
    Marginal zone B cells10.34 ± 4.2710.57 ± 2.31
    Follicular B cells20.32 ± 7.7919.45 ± 1.66
    Mature B cells37.34 ± 12.4038.42 ± 7.86
    Monocytes0.97 ± 0.310.83 ± 0.12
    Neutrophils0.94 ± 0.280.51 ± 0.14
    CD3+CD4+ cells10.59 ± 3.104.60 ± 0.70a
    CD3+CD8+ cells2.16 ± 0.450.90 ± 0.11a
    CD3+CD4CD8 cells19.19 ± 3.296.27 ± 2.43a
    Regulatory T Cells11.55 ± 2.879.13 ± 0.85
    Dendritic cells19.15 ± 4.0312.54 ± 3.56
    Macrophages18.27 ± 3.4316.10 ± 1.94
Bone marrow (cells/million) in femur
    Total number of cells61.84 ± 9.7783.25 ± 8.29
    Monocytes5.25 ± 1.209.95 ± 1.11
    Neutrophils35.02 ± 5.4649.76 ± 3.59
    Plasma cells0.26 ± 0.100.28 ± 0.03
    Short-lived plasma cells0.11 ± 0.030.09 ± 0.02
    Long-lived plasma cells0.14 ± 0.060.19 ± 0.01
Blood
    Neutrophils (cells/μl)2096.27 ± 221.382123.6 ± 389.12
    Lymphocytes (cells/μl)4029.72 ± 872.104176.8 ± 1103.5
    Monocytes (cells/μl)427.9 ± 110.1462.08 ± 164.3
    Eosinophils (cells/μl)54.27 ± 14.728.25 ± 9.8
    Leukocytes (109 cells/L)6.37 ± 1.16.79 ± 1.4
    Erythrocytes (1012 cells/L)9.18 ± 0.158.96 ± 0.23
    Thrombocytes (109 cells/L)954 ± 63.81187 ± 82.1
  • n = 6 per group; data are means ± SEM;

  • aP < 0.05 versus vehicle.