Table 1.

Kidney mRNA expression of key leukocyte chemokines and adhesion molecules in wild-type and mast cell-deficient mice 24 h after treatment

Wild-Type MiceKitW-sh/W-sh MiceSignificance
IP10/CXCL101.0 ± 0.20.1 ± 0.0P < 0.001
RANTES/CXCL51.0 ± 0.10.4 ± 0.1P < 0.01
MCP1/CCL21.0 ± 0.10.2 ± 0.0P < 0.001
KC/CXCL11.0 ± 0.40.1 ± 0.0P < 0.05
MIP2/CXCL21.0 ± 0.20.4 ± 0.2P < 0.05
ICAM-11.0 ± 0.20.2 ± 0.1P < 0.001
VCAM-11.0 ± 0.30.3 ± 0.1P = 0.06
  • Twenty-four hours after administration of cisplatin expression of key T cell chemokines (CXCL10, CXCL5, and CCL2) and neutrophil chemo-attractants (CXCL1 and CXCL2) were decreased in KitW-sh/W-sh mice (n = 8) compared with WT mice (n = 8). Expression of adhesion molecules demonstrated a decrease in ICAM-1 with a trend to decrease in VCAM-1 expression in KitW-sh/W-sh mice.