Table 5.

Analysis of rate of decline of renal function and outcome

ParameterRateof Decline of eGFR (ml/min per 1.73 m2 per year)Factors Associated with Bad Outcomea
Multiple Linear RegressionF(9,82)=5.2877, P<0.00001, R2=0.3672Cox Proportional Hazards Modelingχ2=111.34, df=9, P=0.00000
βSEM βt ValueP ValueβSEM βt ValueP Value
Mesangial hypercellularity0.06680.10820.61740.540.69690.40641.71940.09
Segmental glomerulosclerosis0.21540.10062.1430.04−0.78730.6667−1.18090.24
Endocapillary proliferation0.15020.11301.32980.19−0.03680.4029−0.09140.93
Percentage tubular atrophy/interstitial fibrosis0.29260.14841.97160.050.00330.01030.32170.74
Proteinuria Dx0.09570.11240.09640.37−0.01830.0561−0.32630.74
eGFR Dx0.40520.15142.5760.01−0.09230.0209−4.42230.00001
Mean arterial pressure Dx0.01080.11190.85150.920.00030.00850.03620.97
Morphologic TMA0.08170.11750.69580.490.63940.54881.16510.24
Laboratory evidence of TMA0.33670.09593.51280.0011.33340.60692.19900.03
  • Bold designates P<0.05. Dx, diagnosis.

  • aBad outcome defined as doubling serum creatinine or ESRD.