Table 2.

Clinical and morphologic differences between patients with normotension, moderate hypertension, and MHT at the time of diagnosis

ParameterNormotensive, No AntihypertensorsP ValueNormotensive on AntihypertensorsP ValueHypertensionP ValueMHTP Value (Versus Normotensive without Treatment)
Number of patients19444718
Systolic BP Dx (mmHg)119 (114–127)0.01126 (120–133)0.00162 (150–170)0.001193 (164–220)0.00
Diastolic BP Dx (mmHg)72 (62–80)>0.1073 (66–80)0.0095 (88–100)0.002111 (97–125)0.000001
SCr Dx (μmol/L)113 (79–141)>0.10173 (81–163)0.001215 (126–136)0.0001739 (248–1316)0.000003
eGFR Dx (ml/min per 1.73 m2)77 (68–89)>0.1063 (44–89)0.00244.3 (26.4–55.6)0.0000115.8 (4.3–20.0)0.000001
Proteinuria Dx (g/day)1.01 (0.11–1.90)>0.101.42 (0.66–2.00)0.00043.34 (1.10–4.05)>0.104.21 (2.00–6.40)0.00004
Laboratory evidence of TMA0 of 16 = 0>0.101 of 41 = 2.4%>0.102 of 45 = 4.5%0.015 of 18 = 27.7%0.03
TMA
 arterial
  acute, with fibrin0 of 19 = 0>0.102 of 44 = 4.5%>0.106 of 47 = 12.8%>0.106 of 18 = 33.3%0.001
  organized0 of 19 = 0>0.103 of 44 = 6.8%0.0311 of 47 = 23.4%>0.106 of 18 = 33.3%0.001
 arteriolar
  acute, with fibrin1 of 19 = 5.2%>0.105 of 44 = 11.3%>0.109 of 47 = 19.1%>0.104 of 18 = 22.2%>0.10
  organized3 of 19 = 15.8%>0.1013 of 44 = 29.5%0.0225 of 47 = 53.2%>0.1011 of 18 = 61.1%0.005
Any TMA (acute or organized, arterial or arteriolar)3 of 19 = 15.8%0.0717 of 44 = 38.6%0.0131 of 47 = 65.9%0.00418 of 18 = 100%0.00
Bad outcomea1 of 19 = 5.2%>0.108 of 44 = 18.2%0.0417 of 45 = 37.8%0.00214 of 17 = 82.3%0.00
RRT0 of 19 = 00.058 of 44 = 18.2%>0.1013 of 45 = 28.9%0.000214 of 17 = 82.3%0.00
Immediate RRTb0 of 19 = 0>0.104 of 44 = 9.1%>0.103 of 45 = 6.7%0.00029 of 17 = 57.9%0.0003
  • Values expressed as mean (25th to 75th percentile) or percentages. P values calculated by Mann–Whitney U test or Fisher’s exact test as appropriate. BP, blood pressure; Dx, diagnosis.

  • aBad outcome is defined as doubling of SCr or need for dialysis.

  • bImmediate RRT is defined by RRT initiation <3 months after biopsy.