Table 1.

 Comparison of clinical data between patients with and without TMA

ParameterTMANo TMAP Value
Number of patients6860
Age (years)39.7 (29–49)36.2 (26–44)>0.10
Male49 of 68 = 72.1%41 of 60 = 68.3%>0.10
Initial systolic BP (mmHg)161 (135–177)130 (120–140)0.00
Initial diastolic BP (mmHg)94 (80–107)77 (67–85)0.000002
Percentage hypertensive48 of 68 = 70.6%14 of 60 = 23.3%0.00
Percentage MHT18 of 68 = 26%0 of 60 = 00.00
Final systolic BP (mmHg)131 (120–144)122 (110–130)0.004
Final diastolic BP (mmHg)81 (72–87)74 (69–80)>0.10a
Number of antihypertensive agents2.8 (2–4)1.4 (1–2)0.00
Proteinuria Dx (g/day)3.37 (1.2–4.0)1.33 (0.40–1.85)0.00
Macroscopic hematuria11 of 59 = 18.6%22 of 46 = 47.8%0.0014
Serum albumin (g/L)34.6 (30–39)39.8 (36–43)0.0001
Initial SCr (μmol/L)368 (140–412)123 (80–130)0.00
eGFR (ml/min per 1.73 m2)34 (14–50)73 (51–90)0.00
Final SCr (μmol/L)340 (123–569)156 (81–119)0.00
Final eGFR (ml/min per 1.73 m2)23 (0–49)69 (50–96)0.00
Bad outcomeb34 of 68 = 50.0%6 of 53 = 11.3%0.00
RRT30 of 68 = 44.1%5 of 53 = 9.4%0.00
Laboratory evidence of TMA8 of 65 = 12.3%0 of 55 = 00.01
Family history5 of 53 = 9.4%7 of 39 = 17.9%>0.10
  • Values expressed as mean (25th to 75th percentile) or percentages. P values calculated by Mann–Whitney U test or Fisher’s exact test as appropriate. BP, blood pressure; Dx, diagnosis.

  • aValue of >0.10 after Holm–Bonferroni correction to minimize type 1 error (α=0.05).

  • bBad outcome defined as doubling of initial SCr or need for dialysis.