Table 4.

Univariate analysis of clinical and vascular factors associated with bad outcome

Bad OutcomeaPreservedRenalFunctionP Value
Number of patients4081
Clinical parameters
 systolic Dx (mmHg)167 (140–197)139 (120–150)0.000002
 diastolic Dx (mmHg)97 (80–115)82 (70–90)0.0002
 HBP Dx37 of 40 = 92.5%55 of 81 = 67.9%0.003
 systolic BP, end136 (124–154)123 (111–130)0.000001
 MHT14 of 40 = 35%3 of 81 = 3.7%0.00
 proteinuria Dx (g/day)3.99 (1.81–5.30)1.81 (0.49–2.52)0.000001
 proteinuria, end (g/day)3.32 (1.80–4.92)0.94 (0.10–1.07)0.0001
 serum albumin (g/L)32.6±1.0839.1±0.640.000004
 SCr Dx (μmol/L)537 (190–759)125 (89–161)0.00
 eGFR Dx (ml/min per 1.73 m2)22 (6–34)66 (44–83)0.00
 laboratory evidence of TMA8 of 38 = 21.1%0 of 78 = 00.00
Vascular parameters (arbitrary units)
 arteriosclerosis, global2.34 (2–3)1.72 (1–2)0.01
 arterial intimal sclerosis1.59 (1–3)0.99 (0–2)0.01
 arterial S/M hypertrophy0.99 (0–2)0.52 (0–1)0.002
 arterial hyalin deposits0.42 (0–1)0.24 (0–0)0.06
 arteriolar lumen caliber2.04 (1.5–2.0)2.60 (2–3)0.000001
 arteriolar S/M hypertrophy0.67 (0–1)0.38 (0–1)0.003
 arteriolar hyalin deposits0.82 (0–1)0.81 (0–1.5)>0.10
TMA by vessel size
 arterial fibrinoid TMA11 of 40 = 27.5%4 of 81 = 4.9%0.0004
 arterial organized TMA10 of 40 = 25%11 of 81 = 13.6%>0.10
 arteriolar fibrinoid TMA10 of 40 = 25%9 of 81 = 11.1%0.05
 arteriolar organized TMA25 of 40 = 62.5%26 of 81 = 32.1%0.0014
TMA: all vessels
 fibrinoid TMA22 of 40 = 55%19 of 81 = 23.5%0.001
 organized TMA29 of 40 = 72.5%28 of 81 = 34.6%0.0001
 any TMA34 of 40 = 85%34 of 81 = 42%0.00
  • Values expressed as mean (25th to 75th percentile) or percentages. P values calculated by Mann–Whitney U test or Fisher’s exact test as appropriate. Dx, diagnosis, HBP, high BP; MHT, malignant hypertension; S/M, smooth muscle.

  • a Bad outcome defined as doubling of SCr or need for dialysis.