Table 3.

Roadmap of key topics for future research on the renal mononuclear phagocytic system

General
 identify markers that indicate specific functions of rMoPh
 delineate the functions of glomerular rMoPh from tubulointerstitial rMoPh
 correlate murine with human rMoPh subsets and functions
Ontogeny
 define the precursors and factors that differentiate rMoPh subsets
 define the developmental heterogeneity of rMoPh along the nephron
Surveillance
 define the repertoire of surveillance mechanisms used by rMoPh
 define the extent of differential surveillance by rMoPh along the nephron
Tolerance
 identify the cues that enhance or break peripheral tolerance by rMoPh
 identify the subsets of rMoPh involved in peripheral tolerance
Tissue cytoprotection
 identify the cues that enhance or diminish cytoprotection by rMoPh
 identify the subsets of rMoPh involved in cytoprotection
From steady state to inflammation
 delineate the migratory patterns and chemotactic factors for resident and recruited rMoPh
 identify the subsets of rMoPh that promote versus retard inflammation after injury
Immunity
 define the mechanisms of antigen capture and presentation along the nephron
 define the role of resident versus recruited rMoPh in programming T lymphocytes
Tissue injury
 define the cytotoxic contribution of resident versus recruited rMoPh
 define the fibrogenic and fibrolytic contribution of resident versus recruited rMoPh
Tissue repair
 define the overlapping programs by rMoPh to support nephrogenesis and tissue repair
 define the interaction of rMoPh with tissue-resident progenitors/stem cells
Plasticity
 determine the differences in plasticity of resident versus recruited rMoPh
 define the molecular mechanisms of plasticity of rMoPh during injury and repair