Table 4.

Key conclusions

At steady state, subsets of rMoPh exist that coexpress markers previously thought to segregate Mø and DCs. These cells exhibit functional properties considered typical of both DCs and Mø.
The renal mononuclear phagocytic system performs important homeostatic and sentinel functions in the steady-state kidney and maintains immune tolerance against self- and innocuous antigens.
The renal mononuclear phagocytic system changes dramatically during injury to the kidney, with resident and recruited rMoPh exhibiting functional heterogeneity and plasticity in defense against microbes, mediation of parenchymal injury, and promotion of tissue repair.