Table 4.

Multivariate Cox proportional hazard models of the risk of ESRD in patients with T2D with clinical predictors and the plasma concentration of a TNF marker stratified according to the presence of proteinuria

NonproteinuriaProteinuria
HRa (95% CI)P ValueHRa (95% CI)P Value
Clinical predictorb
 HbA1c1.56 (0.86, 2.82)0.141.24 (0.96, 1.61)0.10
 AER2.23 (1.11, 4.48)0.022.52 (1.14, 5.56)0.02
 eGFR1.10 (0.72, 1.67)0.671.37 (1.11, 1.69)0.004
Individual markerc
 free TNFα2.22 (1.20, 4.12)0.011.21 (0.81, 1.81)0.34
 total TNFα2.53 (1.25, 5.13)0.012.61 (1.42, 4.81)0.002
 TNFR17.11 (2.13, 23.69)0.00047.05 (2.23, 22.30)0.0018
 TNFR23.82 (1.59, 9.20)0.00085.88 (2.10, 16.43)0.0013
  • a Effect measures are expressed as the HR for a one-quartile increase in the distribution of each covariate except for eGFR, for which it is a one-quartile decrease. Quartile definitions are based on the full cohort.

  • b Clinical predictors examined together with TNFR1.

  • c Individual TNF markers examined together with all three clinical predictors.