Table 1.

Distinct and shared functions of macrophages and dendritic cells in the kidney

 classic functions
  phagocytosis of tissue debris and pathogens
  mediation of tissue injury and disease progression
  activated phenotypes exhibit distinct polarized functionsa
 contemporary additions
  phagocytosis to remodel matrix
  support for nephrogenesis and cell fate decisions
  paracrine role in angiogenesis and epithelial regeneration
  polarized function can be fibrogenic
  potent source of chemokines and cytokinesa
  mediate anti-inflammatory/immunosuppressive effects through innate responsesa
DCs
 classic functions
  phagocytosis of antigen in kidney
  migration to renal lymph nodes
  antigen presentation to T lymphocytes
 contemporary additions
  antigen presentation within the kidney to restimulate or modify infiltrating T lymphocytes
  mediate anti-inflammatory/immunosuppressive effects through innate responses and modulation of T lymphocytes (peripheral tolerance)a
  activated phenotypes exhibit distinct polarized functionsa
  potent source of chemokines and cytokinesa
  • a Overlapping functions.